Drug interactions
Fluvastatin + Leflunomide
Severity: Minor
Fluvastatin and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide, the active metabolite of leflunomide, may weakly inhibit CYP2C9 and raise fluvastatin exposure. This may increase the risk of statin-related muscle effects.
What this interaction means in plain words
Fluvastatin and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Leflunomide belongs to Musculoskeletal.
Why it happens
Weak CYP2C9 inhibition by teriflunomide reduces fluvastatin metabolism.
What to do
Monitor for muscle pain or weakness and consider the lowest effective fluvastatin dose. Check creatine kinase if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Leflunomide?
MediHelp rates the interaction as minor. Fluvastatin and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide, the active metabolite of leflunomide, may weakly inhibit CYP2C9 and raise fluvastatin exposure. This may increase the risk of statin-related muscle effects.
How serious is the interaction between Fluvastatin and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness and consider the lowest effective fluvastatin dose. Check creatine kinase if symptoms arise.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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