Drug interactions
Fluvastatin + Teriflunomide
Severity: Moderate
Fluvastatin and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C8 and may also affect BCRP, and fluvastatin is metabolised mainly by CYP2C9. Exposure to fluvastatin may be increased, raising the potential for dose-related statin effects such as myopathy.
What this interaction means in plain words
Fluvastatin and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide inhibits BCRP and weakly CYP2C8, which may raise fluvastatin exposure.
What to do
Monitor for muscle symptoms and consider using the lowest effective fluvastatin dose. Check creatine kinase if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvastatin and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Teriflunomide
Frequently asked questions
Can I take Fluvastatin with Teriflunomide?
MediHelp rates the interaction as moderate. Fluvastatin and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide inhibits CYP2C8 and may also affect BCRP, and fluvastatin is metabolised mainly by CYP2C9. Exposure to fluvastatin may be increased, raising the potential for dose-related statin effects such as myopathy.
How serious is the interaction between Fluvastatin and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider using the lowest effective fluvastatin dose. Check creatine kinase if myopathy is suspected.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
