Drug interactions
Fluvoxamine + Gemifloxacin
Severity: Moderate
Fluvoxamine and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may raise the risk of ventricular arrhythmia. Fluvoxamine has a lower QT liability than many other psychotropics, so the risk is greatest in patients with other predisposing factors.
What this interaction means in plain words
Fluvoxamine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation; fluvoxamine may also inhibit CYP-mediated clearance of other drugs.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors. Monitor for palpitations or syncope and consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Gemifloxacin?
MediHelp rates the interaction as moderate. Fluvoxamine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may raise the risk of ventricular arrhythmia. Fluvoxamine has a lower QT liability than many other psychotropics, so the risk is greatest in patients with other predisposing factors.
How serious is the interaction between Fluvoxamine and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors. Monitor for palpitations or syncope and consider an alternative antibiotic.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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