Drug interactions
Fluvoxamine + Haloperidol
Severity: Major
Fluvoxamine and Haloperidol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so together they may increase the risk of torsades de pointes. Fluvoxamine can also inhibit CYP2D6 and CYP3A4 to some degree, which may raise haloperidol concentrations and the risk of adverse effects.
What this interaction means in plain words
Fluvoxamine and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus fluvoxamine inhibition of haloperidol metabolism via CYP enzymes.
What to do
Obtain a baseline and follow-up ECG, check potassium and magnesium, and use the lowest effective haloperidol dose. Monitor for extrapyramidal effects and consider an alternative if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Haloperidol?
MediHelp rates the interaction as major. Fluvoxamine and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so together they may increase the risk of torsades de pointes. Fluvoxamine can also inhibit CYP2D6 and CYP3A4 to some degree, which may raise haloperidol concentrations and the risk of adverse effects.
How serious is the interaction between Fluvoxamine and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG, check potassium and magnesium, and use the lowest effective haloperidol dose. Monitor for extrapyramidal effects and consider an alternative if the QTc becomes significantly prolonged.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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