Drug interactions
Fluvoxamine + Lasmiditan
Severity: Moderate
Fluvoxamine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a 5-HT1F agonist and the labeling mentions a theoretical risk of serotonin syndrome with serotonergic drugs. Clinical evidence of this with SSRIs is limited.
What this interaction means in plain words
Fluvoxamine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Potential additive serotonergic activity; lasmiditan lacks vasoconstrictive 5-HT1B activity.
What to do
Counsel patients to report agitation, tremor, sweating, diarrhea or fever after dosing. Stop lasmiditan and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Fluvoxamine with Lasmiditan?
MediHelp rates the interaction as moderate. Fluvoxamine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a 5-HT1F agonist and the labeling mentions a theoretical risk of serotonin syndrome with serotonergic drugs. Clinical evidence of this with SSRIs is limited.
How serious is the interaction between Fluvoxamine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating, diarrhea or fever after dosing. Stop lasmiditan and treat if serotonin syndrome is suspected.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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