Drug interactions
Fluvoxamine + Lornoxicam
Severity: Moderate
Fluvoxamine and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs and NSAIDs together raise the risk of gastrointestinal bleeding beyond either alone. The risk is greater in older patients or those with prior ulcers.
What this interaction means in plain words
Fluvoxamine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Lornoxicam belongs to Musculoskeletal.
Why it happens
SSRI-induced platelet serotonin depletion combined with NSAID platelet inhibition and gastric mucosal injury.
What to do
Avoid the combination in high-risk patients or add a proton pump inhibitor for gastroprotection. Monitor for melena, hematemesis and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Fluvoxamine with Lornoxicam?
MediHelp rates the interaction as moderate. Fluvoxamine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs and NSAIDs together raise the risk of gastrointestinal bleeding beyond either alone. The risk is greater in older patients or those with prior ulcers.
How serious is the interaction between Fluvoxamine and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in high-risk patients or add a proton pump inhibitor for gastroprotection. Monitor for melena, hematemesis and anemia.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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