Drug interactions
Fluvoxamine + Mefenamic acid
Severity: Moderate
Fluvoxamine and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine combined with an NSAID increases the risk of upper gastrointestinal bleeding. Fluvoxamine also inhibits CYP2C9, which may raise mefenamic acid levels.
What this interaction means in plain words
Fluvoxamine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Mefenamic acid belongs to Musculoskeletal.
Why it happens
SSRI-induced platelet serotonin depletion adds to NSAID platelet inhibition and mucosal injury.
What to do
Avoid prolonged co-use and consider proton pump inhibitor gastroprotection in at-risk patients. Advise reporting melena or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Mefenamic acid?
MediHelp rates the interaction as moderate. Fluvoxamine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine combined with an NSAID increases the risk of upper gastrointestinal bleeding. Fluvoxamine also inhibits CYP2C9, which may raise mefenamic acid levels.
How serious is the interaction between Fluvoxamine and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged co-use and consider proton pump inhibitor gastroprotection in at-risk patients. Advise reporting melena or hematemesis.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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