Drug interactions
Fluvoxamine + Mirabegron
Severity: Minor
Fluvoxamine and Mirabegron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is cleared mainly by CYP2D6 and CYP1A2, so mirabegron may modestly raise its concentrations. Increased nausea, sedation or other dose-related effects are possible.
What this interaction means in plain words
Fluvoxamine and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, slightly reducing fluvoxamine metabolism.
What to do
No routine adjustment is needed; monitor tolerability and reduce the fluvoxamine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Mirabegron?
MediHelp rates the interaction as minor. Fluvoxamine and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine is cleared mainly by CYP2D6 and CYP1A2, so mirabegron may modestly raise its concentrations. Increased nausea, sedation or other dose-related effects are possible.
How serious is the interaction between Fluvoxamine and Mirabegron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor tolerability and reduce the fluvoxamine dose if adverse effects occur.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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