Drug interactions
Fluvoxamine + Nabumetone
Severity: Moderate
Fluvoxamine and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine used with an NSAID increases the likelihood of upper gastrointestinal bleeding, as seen with other SSRIs. Risk is higher in elderly patients and those with ulcer history.
What this interaction means in plain words
Fluvoxamine and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Nabumetone belongs to Musculoskeletal.
Why it happens
SSRI-induced depletion of platelet serotonin impairs platelet aggregation, adding to NSAID antiplatelet and mucosal-damaging effects.
What to do
Consider a proton pump inhibitor in patients needing both drugs, or use a non-NSAID analgesic such as paracetamol. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Nabumetone?
MediHelp rates the interaction as moderate. Fluvoxamine and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine used with an NSAID increases the likelihood of upper gastrointestinal bleeding, as seen with other SSRIs. Risk is higher in elderly patients and those with ulcer history.
How serious is the interaction between Fluvoxamine and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in patients needing both drugs, or use a non-NSAID analgesic such as paracetamol. Monitor for signs of GI bleeding.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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