Drug interactions
Fluvoxamine + Nisoldipine
Severity: Moderate
Fluvoxamine and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine can raise nisoldipine plasma concentrations because nisoldipine is a sensitive CYP3A4 substrate with high first-pass metabolism. This may cause excessive vasodilation with hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Fluvoxamine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Nisoldipine belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and hepatic CYP3A4 metabolism of nisoldipine by fluvoxamine.
What to do
Monitor blood pressure and heart rate when starting or stopping fluvoxamine, and lower the nisoldipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Nisoldipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Fluvoxamine with Nisoldipine?
MediHelp rates the interaction as moderate. Fluvoxamine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine can raise nisoldipine plasma concentrations because nisoldipine is a sensitive CYP3A4 substrate with high first-pass metabolism. This may cause excessive vasodilation with hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Fluvoxamine and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping fluvoxamine, and lower the nisoldipine dose if hypotension or edema occurs.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
