Drug interactions
Fluvoxamine + Ospemifene
Severity: Moderate
Fluvoxamine and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP2C19, which contributes to ospemifene metabolism, and may increase ospemifene exposure. Higher levels could increase estrogen-agonist effects on the endometrium and risk of thromboembolic events or hot flushes.
What this interaction means in plain words
Fluvoxamine and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Ospemifene belongs to Endocrine.
Why it happens
Inhibition of CYP2C19 (and CYP3A4) metabolism of ospemifene by fluvoxamine.
What to do
Monitor for ospemifene adverse effects, including vaginal bleeding and thromboembolic symptoms; consider an alternative to fluvoxamine if prolonged co-therapy is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Ospemifene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Fluvoxamine with Ospemifene?
MediHelp rates the interaction as moderate. Fluvoxamine and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP2C19, which contributes to ospemifene metabolism, and may increase ospemifene exposure. Higher levels could increase estrogen-agonist effects on the endometrium and risk of thromboembolic events or hot flushes.
How serious is the interaction between Fluvoxamine and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ospemifene adverse effects, including vaginal bleeding and thromboembolic symptoms; consider an alternative to fluvoxamine if prolonged co-therapy is problematic.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
