Drug interactions
Fluvoxamine + Oxaliplatin
Severity: Moderate
Fluvoxamine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation, and fluvoxamine might add a minor effect. The risk is mainly relevant with electrolyte disturbances from chemotherapy such as hypokalemia or hypomagnesemia.
What this interaction means in plain words
Fluvoxamine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Possible additive QT interval prolongation.
What to do
Monitor electrolytes and consider ECG monitoring, especially with vomiting, diarrhea, or other QT-prolonging drugs. Correct potassium and magnesium before treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Oxaliplatin?
MediHelp rates the interaction as moderate. Fluvoxamine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation, and fluvoxamine might add a minor effect. The risk is mainly relevant with electrolyte disturbances from chemotherapy such as hypokalemia or hypomagnesemia.
How serious is the interaction between Fluvoxamine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes and consider ECG monitoring, especially with vomiting, diarrhea, or other QT-prolonging drugs. Correct potassium and magnesium before treatment.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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