Drug interactions
Fluvoxamine + Peginterferon alfa 2b
Severity: Minor
Fluvoxamine and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may modestly alter drug-metabolizing enzyme activity, but the effect on fluvoxamine is unpredictable and likely small. Fluvoxamine is itself a strong CYP1A2 inhibitor and a mainly CYP2D6-metabolized drug.
What this interaction means in plain words
Fluvoxamine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2D6; not firmly established.
What to do
Monitor antidepressant response and adverse effects such as nausea and sedation. Adjust the fluvoxamine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Fluvoxamine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may modestly alter drug-metabolizing enzyme activity, but the effect on fluvoxamine is unpredictable and likely small. Fluvoxamine is itself a strong CYP1A2 inhibitor and a mainly CYP2D6-metabolized drug.
How serious is the interaction between Fluvoxamine and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and adverse effects such as nausea and sedation. Adjust the fluvoxamine dose if needed.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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