Drug interactions
Fluvoxamine + Perphenazine
Severity: Moderate
Fluvoxamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is metabolized by CYP2D6, and fluvoxamine can raise its levels modestly, increasing sedation and extrapyramidal effects. Both drugs may also prolong the QT interval.
What this interaction means in plain words
Fluvoxamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and fluvoxamine-related inhibition of perphenazine metabolism.
What to do
Use the lowest effective perphenazine dose and monitor for extrapyramidal symptoms and sedation. Obtain an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Fluvoxamine with Perphenazine?
MediHelp rates the interaction as moderate. Fluvoxamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is metabolized by CYP2D6, and fluvoxamine can raise its levels modestly, increasing sedation and extrapyramidal effects. Both drugs may also prolong the QT interval.
How serious is the interaction between Fluvoxamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective perphenazine dose and monitor for extrapyramidal symptoms and sedation. Obtain an ECG if other QT risk factors are present.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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