Drug interactions
Fluvoxamine + Rimegepant
Severity: Minor
Fluvoxamine and Rimegepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is metabolized mainly by CYP3A4, and fluvoxamine is a weak CYP3A4 inhibitor that may modestly increase rimegepant exposure. The effect is usually small, but labeling for moderate CYP3A4 inhibitors recommends limiting dosing frequency.
What this interaction means in plain words
Fluvoxamine and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Rimegepant belongs to Central Nervous System.
Why it happens
Fluvoxamine weakly inhibits CYP3A4, reducing rimegepant clearance.
What to do
No routine adjustment is needed with a weak inhibitor, but avoid repeating a rimegepant dose within 48 hours if a stronger CYP3A4 inhibitor is also on board. Monitor for adverse effects such as nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Fluvoxamine with Rimegepant?
MediHelp rates the interaction as minor. Fluvoxamine and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rimegepant is metabolized mainly by CYP3A4, and fluvoxamine is a weak CYP3A4 inhibitor that may modestly increase rimegepant exposure. The effect is usually small, but labeling for moderate CYP3A4 inhibitors recommends limiting dosing frequency.
How serious is the interaction between Fluvoxamine and Rimegepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed with a weak inhibitor, but avoid repeating a rimegepant dose within 48 hours if a stronger CYP3A4 inhibitor is also on board. Monitor for adverse effects such as nausea.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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