Drug interactions
Fluvoxamine + Ritlecitinib
Severity: Minor
Fluvoxamine and Ritlecitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib can inhibit CYP1A2, but fluvoxamine is a CYP1A2 inhibitor and substrate only to a limited degree. The effect on fluvoxamine exposure is expected to be small and unlikely to be clinically significant.
What this interaction means in plain words
Fluvoxamine and Ritlecitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Ritlecitinib belongs to Oncology.
Why it happens
Predicted weak CYP1A2 inhibition by ritlecitinib may slightly reduce fluvoxamine clearance.
What to do
No routine dose change is needed; monitor for fluvoxamine adverse effects such as nausea or sedation when starting ritlecitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Fluvoxamine with Ritlecitinib?
MediHelp rates the interaction as minor. Fluvoxamine and Ritlecitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritlecitinib can inhibit CYP1A2, but fluvoxamine is a CYP1A2 inhibitor and substrate only to a limited degree. The effect on fluvoxamine exposure is expected to be small and unlikely to be clinically significant.
How serious is the interaction between Fluvoxamine and Ritlecitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for fluvoxamine adverse effects such as nausea or sedation when starting ritlecitinib.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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