Drug interactions
Fluvoxamine + Talquetamab
Severity: Moderate
Fluvoxamine and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzyme activity and increase exposure to CYP substrates. Fluvoxamine levels may rise around step-up dosing and during CRS, increasing its adverse effects.
What this interaction means in plain words
Fluvoxamine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP450 activity, including CYP1A2, reducing fluvoxamine clearance.
What to do
Monitor for fluvoxamine adverse effects such as nausea, sedation and serotonergic symptoms during the first weeks of talquetamab and during CRS; reduce the fluvoxamine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Fluvoxamine with Talquetamab?
MediHelp rates the interaction as moderate. Fluvoxamine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzyme activity and increase exposure to CYP substrates. Fluvoxamine levels may rise around step-up dosing and during CRS, increasing its adverse effects.
How serious is the interaction between Fluvoxamine and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fluvoxamine adverse effects such as nausea, sedation and serotonergic symptoms during the first weeks of talquetamab and during CRS; reduce the fluvoxamine dose if toxicity appears.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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