Drug interactions
Fluvoxamine + Tazemetostat
Severity: Moderate
Fluvoxamine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine can inhibit CYP3A4 to a modest degree and may raise tazemetostat concentrations. Higher exposure could increase tazemetostat adverse effects such as cytopenias and fatigue.
What this interaction means in plain words
Fluvoxamine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Fluvoxamine weakly to moderately inhibits CYP3A4, reducing the metabolic clearance of tazemetostat, a CYP3A4 substrate.
What to do
Monitor for tazemetostat toxicity, particularly hematologic effects. Consider an alternative antidepressant with minimal CYP3A4 inhibition, or follow the tazemetostat labeling for dose reduction with moderate CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Fluvoxamine with Tazemetostat?
MediHelp rates the interaction as moderate. Fluvoxamine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine can inhibit CYP3A4 to a modest degree and may raise tazemetostat concentrations. Higher exposure could increase tazemetostat adverse effects such as cytopenias and fatigue.
How serious is the interaction between Fluvoxamine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat toxicity, particularly hematologic effects. Consider an alternative antidepressant with minimal CYP3A4 inhibition, or follow the tazemetostat labeling for dose reduction with moderate CYP3A4 inhibitors.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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