Drug interactions
Fluvoxamine + Voriconazole
Severity: Moderate
Fluvoxamine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP2C19 and CYP3A4 and can raise voriconazole levels, while both agents have QT-prolonging potential. The combination may increase the risk of QT prolongation and voriconazole toxicity.
What this interaction means in plain words
Fluvoxamine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Fluvoxamine inhibits CYP2C19 and CYP3A4, raising voriconazole levels, with additive QT effects.
What to do
Monitor the ECG and electrolytes and watch for voriconazole adverse effects such as visual disturbance and hepatotoxicity. Consider voriconazole trough monitoring or an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Voriconazole?
MediHelp rates the interaction as moderate. Fluvoxamine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP2C19 and CYP3A4 and can raise voriconazole levels, while both agents have QT-prolonging potential. The combination may increase the risk of QT prolongation and voriconazole toxicity.
How serious is the interaction between Fluvoxamine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes and watch for voriconazole adverse effects such as visual disturbance and hepatotoxicity. Consider voriconazole trough monitoring or an alternative antidepressant.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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