Drug interactions
Fondaparinux + Gemcitabine
Severity: Moderate
Fondaparinux and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine commonly causes thrombocytopenia, which increases bleeding risk in patients on anticoagulants. The risk is greatest around the platelet nadir.
What this interaction means in plain words
Fondaparinux and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Gemcitabine belongs to Oncology.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia; no direct pharmacokinetic interaction with fondaparinux.
What to do
Monitor platelet counts before each cycle and hold or reduce anticoagulation if platelets fall significantly. Watch for bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Gemcitabine
Frequently asked questions
Can I take Fondaparinux with Gemcitabine?
MediHelp rates the interaction as moderate. Fondaparinux and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine commonly causes thrombocytopenia, which increases bleeding risk in patients on anticoagulants. The risk is greatest around the platelet nadir.
How serious is the interaction between Fondaparinux and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts before each cycle and hold or reduce anticoagulation if platelets fall significantly. Watch for bleeding signs.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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