Drug interactions
Fondaparinux + Lornoxicam
Severity: Major
Fondaparinux and Lornoxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam inhibits platelet function and can injure the gastric mucosa, so with fondaparinux the risk of bleeding, particularly gastrointestinal, is increased. Risk is higher in older patients and with renal impairment, which also raises fondaparinux exposure.
What this interaction means in plain words
Fondaparinux and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fondaparinux belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive impairment of hemostasis from NSAID platelet inhibition and mucosal injury plus factor Xa inhibition.
What to do
Avoid the combination where possible and use paracetamol instead. If unavoidable, use the lowest dose briefly with gastroprotection and monitor hemoglobin and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Fondaparinux with Lornoxicam?
MediHelp rates the interaction as major. Fondaparinux and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lornoxicam inhibits platelet function and can injure the gastric mucosa, so with fondaparinux the risk of bleeding, particularly gastrointestinal, is increased. Risk is higher in older patients and with renal impairment, which also raises fondaparinux exposure.
How serious is the interaction between Fondaparinux and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol instead. If unavoidable, use the lowest dose briefly with gastroprotection and monitor hemoglobin and renal function.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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