Drug interactions
Fondaparinux + Pegaspargase
Severity: Moderate
Fondaparinux and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase lowers synthesis of coagulation proteins and can cause both bleeding and thrombosis. Added to fondaparinux, this may raise bleeding risk, and fondaparinux may be needed for asparaginase-associated thrombosis.
What this interaction means in plain words
Fondaparinux and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Pegaspargase belongs to Oncology.
Why it happens
Asparaginase-induced reduction in clotting factors and fibrinogen adds to anticoagulant effect.
What to do
Monitor fibrinogen, platelet count and bleeding signs, and review anticoagulant dosing if coagulopathy develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Fondaparinux with Pegaspargase?
MediHelp rates the interaction as moderate. Fondaparinux and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase lowers synthesis of coagulation proteins and can cause both bleeding and thrombosis. Added to fondaparinux, this may raise bleeding risk, and fondaparinux may be needed for asparaginase-associated thrombosis.
How serious is the interaction between Fondaparinux and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fibrinogen, platelet count and bleeding signs, and review anticoagulant dosing if coagulopathy develops.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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