Drug interactions
Fondaparinux + Tipranavir
Severity: Moderate
Fondaparinux and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir boosted with ritonavir has been associated with bleeding events including intracranial hemorrhage and may impair platelet aggregation. Concurrent anticoagulants may add to the risk.
What this interaction means in plain words
Fondaparinux and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Antiplatelet activity of tipranavir adds to factor Xa inhibition.
What to do
Monitor for bleeding and consider alternatives to tipranavir in patients at high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Fondaparinux with Tipranavir?
MediHelp rates the interaction as moderate. Fondaparinux and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir boosted with ritonavir has been associated with bleeding events including intracranial hemorrhage and may impair platelet aggregation. Concurrent anticoagulants may add to the risk.
How serious is the interaction between Fondaparinux and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider alternatives to tipranavir in patients at high bleeding risk.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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