Drug interactions
Formoterol-mometasone + Lopinavir
Severity: Moderate
Formoterol-mometasone and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, boosted with ritonavir, inhibits CYP3A4 and can increase systemic mometasone exposure. This raises the risk of adrenal suppression and Cushing's syndrome.
What this interaction means in plain words
Formoterol-mometasone and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Lopinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 mediated mometasone metabolism.
What to do
Monitor for hypercortisolism and adrenal suppression with prolonged use. Consider an alternative corticosteroid such as beclomethasone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Lopinavir?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, boosted with ritonavir, inhibits CYP3A4 and can increase systemic mometasone exposure. This raises the risk of adrenal suppression and Cushing's syndrome.
How serious is the interaction between Formoterol-mometasone and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypercortisolism and adrenal suppression with prolonged use. Consider an alternative corticosteroid such as beclomethasone for long-term therapy.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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