Drug interactions
Formoterol-mometasone + Sotalol
Severity: Major
Formoterol-mometasone and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a non-selective beta-blocker that antagonizes formoterol's bronchodilator effect and may cause bronchospasm in patients with airway disease. Both drugs can also prolong QT or lower potassium, adding to arrhythmia risk.
What this interaction means in plain words
Formoterol-mometasone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Sotalol belongs to Cardiovascular.
Why it happens
Beta-2 receptor blockade by sotalol opposes formoterol, with additive QT-prolonging and potassium-lowering effects.
What to do
Avoid sotalol in patients with asthma or COPD who need formoterol and choose another antiarrhythmic. If unavoidable, monitor respiratory status, ECG and potassium closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol-mometasone
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Sotalol?
MediHelp rates the interaction as major. Formoterol-mometasone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a non-selective beta-blocker that antagonizes formoterol's bronchodilator effect and may cause bronchospasm in patients with airway disease. Both drugs can also prolong QT or lower potassium, adding to arrhythmia risk.
How serious is the interaction between Formoterol-mometasone and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sotalol in patients with asthma or COPD who need formoterol and choose another antiarrhythmic. If unavoidable, monitor respiratory status, ECG and potassium closely.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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