Drug interactions
Fosaprepitant + Ivabradine
Severity: Moderate
Fosaprepitant and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor and can raise ivabradine exposure. This may cause bradycardia, though a single dose has a transient effect.
What this interaction means in plain words
Fosaprepitant and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Ivabradine belongs to Cardiovascular.
Why it happens
Aprepitant inhibits CYP3A4, reducing ivabradine metabolism.
What to do
Monitor heart rate and ECG for several days after dosing. Consider holding or lowering ivabradine if bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Ivabradine?
MediHelp rates the interaction as moderate. Fosaprepitant and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor and can raise ivabradine exposure. This may cause bradycardia, though a single dose has a transient effect.
How serious is the interaction between Fosaprepitant and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG for several days after dosing. Consider holding or lowering ivabradine if bradycardia develops.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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