Drug interactions
Fosaprepitant + Liposomal doxorubicin
Severity: Minor
Fosaprepitant and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a weak to moderate CYP3A4 inhibitor after a single dose, with a transient effect. A clinically important rise in doxorubicin exposure is unlikely, but it is possible.
What this interaction means in plain words
Fosaprepitant and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Liposomal doxorubicin belongs to Oncology.
Why it happens
Aprepitant transiently inhibits CYP3A4, slightly reducing doxorubicin metabolism.
What to do
Fosaprepitant is commonly used as antiemetic prophylaxis with anthracyclines; no change is usually needed beyond routine toxicity monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Fosaprepitant and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, via aprepitant, is a weak to moderate CYP3A4 inhibitor after a single dose, with a transient effect. A clinically important rise in doxorubicin exposure is unlikely, but it is possible.
How serious is the interaction between Fosaprepitant and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Fosaprepitant is commonly used as antiemetic prophylaxis with anthracyclines; no change is usually needed beyond routine toxicity monitoring.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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