Drug interactions
Fosaprepitant + Lovastatin
Severity: Minor
Fosaprepitant and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, converted to aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose and may modestly raise lovastatin levels. Clinical significance is usually low given the short exposure, so a contraindication is not warranted.
What this interaction means in plain words
Fosaprepitant and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Lovastatin belongs to Cardiovascular.
Why it happens
Transient, modest CYP3A4 inhibition by aprepitant reduces lovastatin metabolism.
What to do
No routine adjustment is needed for single-dose use; advise the patient to report muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Lovastatin?
MediHelp rates the interaction as minor. Fosaprepitant and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, converted to aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose and may modestly raise lovastatin levels. Clinical significance is usually low given the short exposure, so a contraindication is not warranted.
How serious is the interaction between Fosaprepitant and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for single-dose use; advise the patient to report muscle pain or weakness.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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