Drug interactions
Fosaprepitant + Ribociclib
Severity: Moderate
Fosaprepitant and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a CYP3A4 substrate and a dose-dependent moderate CYP3A4 inhibitor. Ribociclib may increase aprepitant exposure, and aprepitant may raise ribociclib exposure, increasing QT prolongation risk. Clinical significance is likely modest with single-dose fosaprepitant.
What this interaction means in plain words
Fosaprepitant and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Ribociclib belongs to Oncology.
Why it happens
Mutual CYP3A4 inhibition and substrate competition between ribociclib and aprepitant.
What to do
Monitor ECG and electrolytes when used together, and consider an alternative antiemetic if QTc is prolonged. Watch for ribociclib adverse effects such as neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Ribociclib?
MediHelp rates the interaction as moderate. Fosaprepitant and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a CYP3A4 substrate and a dose-dependent moderate CYP3A4 inhibitor. Ribociclib may increase aprepitant exposure, and aprepitant may raise ribociclib exposure, increasing QT prolongation risk. Clinical significance is likely modest with single-dose fosaprepitant.
How serious is the interaction between Fosaprepitant and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes when used together, and consider an alternative antiemetic if QTc is prolonged. Watch for ribociclib adverse effects such as neutropenia.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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