Drug interactions
Fosaprepitant + Rimegepant
Severity: Moderate
Fosaprepitant and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant (aprepitant) is a moderate CYP3A4 inhibitor that can increase rimegepant exposure. The effect is typically transient after a single fosaprepitant dose but may raise adverse effect risk.
What this interaction means in plain words
Fosaprepitant and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by aprepitant.
What to do
For acute migraine treatment, avoid a second rimegepant dose within 48 hours of coadministration. No adjustment is needed for preventive dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Rimegepant?
MediHelp rates the interaction as moderate. Fosaprepitant and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant (aprepitant) is a moderate CYP3A4 inhibitor that can increase rimegepant exposure. The effect is typically transient after a single fosaprepitant dose but may raise adverse effect risk.
How serious is the interaction between Fosaprepitant and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For acute migraine treatment, avoid a second rimegepant dose within 48 hours of coadministration. No adjustment is needed for preventive dosing.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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