Drug interactions
Fosaprepitant + Saxagliptin
Severity: Minor
Fosaprepitant and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, and given as a single dose its inhibition is modest and transient. Saxagliptin exposure may rise slightly, but this is unlikely to matter clinically.
What this interaction means in plain words
Fosaprepitant and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Saxagliptin belongs to Endocrine.
Why it happens
Weak to moderate transient CYP3A4 inhibition by aprepitant reduces saxagliptin metabolism to its active metabolite.
What to do
No dose change is normally needed with single-dose fosaprepitant; monitor for adverse effects of saxagliptin if repeated dosing is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Saxagliptin?
MediHelp rates the interaction as minor. Fosaprepitant and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, and given as a single dose its inhibition is modest and transient. Saxagliptin exposure may rise slightly, but this is unlikely to matter clinically.
How serious is the interaction between Fosaprepitant and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed with single-dose fosaprepitant; monitor for adverse effects of saxagliptin if repeated dosing is used.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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