Drug interactions
Fosaprepitant + Solifenacin
Severity: Minor
Fosaprepitant and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Single-dose fosaprepitant is a weak, transient CYP3A4 inhibitor, so any rise in solifenacin levels is likely small. Clinical consequences are not expected in most patients.
What this interaction means in plain words
Fosaprepitant and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Solifenacin belongs to Genitourinary.
Why it happens
Weak, short-lived CYP3A4 inhibition by aprepitant, the active metabolite of fosaprepitant.
What to do
No dose adjustment is needed; monitor for anticholinergic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Solifenacin?
MediHelp rates the interaction as minor. Fosaprepitant and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Single-dose fosaprepitant is a weak, transient CYP3A4 inhibitor, so any rise in solifenacin levels is likely small. Clinical consequences are not expected in most patients.
How serious is the interaction between Fosaprepitant and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for anticholinergic adverse effects.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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