Drug interactions
Fosaprepitant + Tacrolimus
Severity: Moderate
Fosaprepitant and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and may modestly increase tacrolimus levels, particularly with repeated dosing. A single dose usually has a limited effect.
What this interaction means in plain words
Fosaprepitant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Tacrolimus belongs to Miscellaneous.
Why it happens
Aprepitant inhibits CYP3A4, reducing tacrolimus metabolism.
What to do
Monitor tacrolimus trough levels and renal function after fosaprepitant doses and adjust the tacrolimus dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Tacrolimus?
MediHelp rates the interaction as moderate. Fosaprepitant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and may modestly increase tacrolimus levels, particularly with repeated dosing. A single dose usually has a limited effect.
How serious is the interaction between Fosaprepitant and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function after fosaprepitant doses and adjust the tacrolimus dose if levels rise.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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