Drug interactions
Foscarnet + Prochlorperazine
Severity: Major
Foscarnet and Prochlorperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet can prolong the QT interval and cause hypocalcemia, hypomagnesemia and hypokalemia. Together with prochlorperazine these effects raise the risk of torsades de pointes.
What this interaction means in plain words
Foscarnet and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, worsened by foscarnet-induced electrolyte disturbances.
What to do
Monitor calcium, magnesium and potassium and replace deficits. Obtain an ECG, and prefer a non-QT-prolonging antiemetic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Prochlorperazine?
MediHelp rates the interaction as major. Foscarnet and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Foscarnet can prolong the QT interval and cause hypocalcemia, hypomagnesemia and hypokalemia. Together with prochlorperazine these effects raise the risk of torsades de pointes.
How serious is the interaction between Foscarnet and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor calcium, magnesium and potassium and replace deficits. Obtain an ECG, and prefer a non-QT-prolonging antiemetic.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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