Drug interactions
Fosinopril-hydrochlorothiazide + Methylprednisolone
Severity: Moderate
Fosinopril-hydrochlorothiazide and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and systemic corticosteroids lower serum potassium, so combining them can produce additive hypokalemia. This may be clinically relevant in patients with heart disease or on other arrhythmogenic drugs. The ACE inhibitor component partially counteracts potassium loss.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Methylprednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide action and corticosteroid effects on the distal nephron.
What to do
Check serum potassium and magnesium periodically during corticosteroid courses and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Methylprednisolone?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and systemic corticosteroids lower serum potassium, so combining them can produce additive hypokalemia. This may be clinically relevant in patients with heart disease or on other arrhythmogenic drugs. The ACE inhibitor component partially counteracts potassium loss.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium periodically during corticosteroid courses and replace as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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