Drug interactions
Fosinopril-hydrochlorothiazide + Pregabalin
Severity: Moderate
Fosinopril-hydrochlorothiazide and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and pregabalin have been associated with angioedema of the face, lips and throat. Using them together may raise the likelihood of this reaction, which can threaten the airway, although such events are uncommon.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
ACE inhibitors cause bradykinin accumulation leading to angioedema, and pregabalin has independently been linked to angioedema, so the risks may be additive.
What to do
Counsel patients to stop both drugs and seek emergency care for swelling of the face, tongue or throat. Review the need for each drug if angioedema occurs and avoid rechallenge with the ACE inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Pregabalin?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and pregabalin have been associated with angioedema of the face, lips and throat. Using them together may raise the likelihood of this reaction, which can threaten the airway, although such events are uncommon.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop both drugs and seek emergency care for swelling of the face, tongue or throat. Review the need for each drug if angioedema occurs and avoid rechallenge with the ACE inhibitor.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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