Drug interactions
Fosinopril-hydrochlorothiazide + Temsirolimus
Severity: Moderate
Fosinopril-hydrochlorothiazide and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus given with an ACE inhibitor raises the risk of angioedema. Swelling of the face, lips, tongue or airway may occur and can be serious.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
mTOR inhibition and ACE inhibition both impair bradykinin breakdown or increase its effects, favouring angioedema.
What to do
Counsel patients to report swelling of the face, lips or throat immediately. Stop the ACE inhibitor and treat if angioedema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Temsirolimus?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus given with an ACE inhibitor raises the risk of angioedema. Swelling of the face, lips, tongue or airway may occur and can be serious.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips or throat immediately. Stop the ACE inhibitor and treat if angioedema develops.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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