Drug interactions
Fosinopril-hydrochlorothiazide + Vitamin d
Severity: Moderate
Fosinopril-hydrochlorothiazide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion and, with vitamin D or its analogs, can lead to hypercalcemia. This is more likely with high vitamin D doses or in renal impairment.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazides increase renal calcium reabsorption while vitamin D increases intestinal calcium absorption, producing additive calcium elevation.
What to do
Monitor serum calcium periodically and reduce vitamin D or stop the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Vitamin d
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Vitamin d?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion and, with vitamin D or its analogs, can lead to hypercalcemia. This is more likely with high vitamin D doses or in renal impairment.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and reduce vitamin D or stop the thiazide if hypercalcemia develops.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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