Drug interactions
Fostamatinib + Lidocaine-prilocaine
Severity: Minor
Fostamatinib and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and could modestly increase concentrations of P-gp substrates. Lidocaine is only a weak P-gp substrate and topical absorption is low, so a meaningful effect is unlikely.
What this interaction means in plain words
Fostamatinib and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Lidocaine-prilocaine belongs to Genitourinary.
Why it happens
Inhibition of P-glycoprotein efflux by the fostamatinib metabolite may slightly raise lidocaine exposure.
What to do
No action is generally needed for routine topical use. Be alert to signs of lidocaine toxicity if large doses are applied.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Fostamatinib and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein and could modestly increase concentrations of P-gp substrates. Lidocaine is only a weak P-gp substrate and topical absorption is low, so a meaningful effect is unlikely.
How serious is the interaction between Fostamatinib and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed for routine topical use. Be alert to signs of lidocaine toxicity if large doses are applied.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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