Drug interactions
Fostamatinib + Mifepristone
Severity: Moderate
Fostamatinib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase exposure to R406, the active metabolite of fostamatinib. This may increase dose-related adverse effects such as hypertension, diarrhea, neutropenia and elevated liver enzymes.
What this interaction means in plain words
Fostamatinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated R406 metabolism by mifepristone.
What to do
Monitor blood pressure, liver enzymes and neutrophil counts. Reduce the fostamatinib dose if toxicities occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Mifepristone?
MediHelp rates the interaction as moderate. Fostamatinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may increase exposure to R406, the active metabolite of fostamatinib. This may increase dose-related adverse effects such as hypertension, diarrhea, neutropenia and elevated liver enzymes.
How serious is the interaction between Fostamatinib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, liver enzymes and neutrophil counts. Reduce the fostamatinib dose if toxicities occur.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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