Drug interactions
Fostamatinib + Paclitaxel
Severity: Moderate
Fostamatinib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite R406 inhibits P-glycoprotein and may increase exposure to paclitaxel, a P-gp substrate. This could intensify paclitaxel toxicities such as myelosuppression and neuropathy.
What this interaction means in plain words
Fostamatinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
R406 inhibits intestinal and cellular P-glycoprotein efflux of paclitaxel.
What to do
Monitor blood counts and neuropathy, and reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Paclitaxel?
MediHelp rates the interaction as moderate. Fostamatinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite R406 inhibits P-glycoprotein and may increase exposure to paclitaxel, a P-gp substrate. This could intensify paclitaxel toxicities such as myelosuppression and neuropathy.
How serious is the interaction between Fostamatinib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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