Drug interactions
Fostamatinib + Quinidine
Severity: Moderate
Fostamatinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may increase the absorption and reduce the elimination of quinidine. Higher quinidine exposure can raise the risk of QT prolongation and other toxicity.
What this interaction means in plain words
Fostamatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Tamatinib inhibits intestinal and renal P-glycoprotein efflux of quinidine.
What to do
Monitor quinidine levels, ECG/QTc and signs of toxicity, and reduce the quinidine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Quinidine?
MediHelp rates the interaction as moderate. Fostamatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may increase the absorption and reduce the elimination of quinidine. Higher quinidine exposure can raise the risk of QT prolongation and other toxicity.
How serious is the interaction between Fostamatinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine levels, ECG/QTc and signs of toxicity, and reduce the quinidine dose if needed.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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