Drug interactions
Fostamatinib + Rosuvastatin
Severity: Moderate
Fostamatinib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib increases exposure to rosuvastatin, which can raise the risk of statin-related myopathy. Its active metabolite inhibits BCRP, a key transporter for rosuvastatin.
What this interaction means in plain words
Fostamatinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
The active metabolite of fostamatinib (R406) inhibits BCRP, reducing rosuvastatin efflux and increasing its systemic exposure.
What to do
Monitor for muscle symptoms and reduce the rosuvastatin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Rosuvastatin?
MediHelp rates the interaction as moderate. Fostamatinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib increases exposure to rosuvastatin, which can raise the risk of statin-related myopathy. Its active metabolite inhibits BCRP, a key transporter for rosuvastatin.
How serious is the interaction between Fostamatinib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and reduce the rosuvastatin dose if adverse effects occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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