Drug interactions
Fostamatinib + Secobarbital
Severity: Moderate
Fostamatinib and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower exposure to the active metabolite of fostamatinib through CYP3A4 induction. This may reduce platelet-raising efficacy in immune thrombocytopenia.
What this interaction means in plain words
Fostamatinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases clearance of the active metabolite R406.
What to do
Monitor platelet counts and consider fostamatinib dose adjustment if response is lost. Prefer a non-inducing sedative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Secobarbital?
MediHelp rates the interaction as moderate. Fostamatinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower exposure to the active metabolite of fostamatinib through CYP3A4 induction. This may reduce platelet-raising efficacy in immune thrombocytopenia.
How serious is the interaction between Fostamatinib and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and consider fostamatinib dose adjustment if response is lost. Prefer a non-inducing sedative where possible.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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