Drug interactions
Fostamatinib + Vardenafil
Severity: Minor
Fostamatinib and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite R406 modestly inhibits CYP3A4 and can increase exposure to CYP3A4 substrates such as vardenafil. This may increase vasodilatory adverse effects.
What this interaction means in plain words
Fostamatinib and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
R406 (tamatinib) weakly inhibits CYP3A4, reducing vardenafil clearance.
What to do
Usually no dose change is needed; monitor for hypotension, headache and flushing and reduce the vardenafil dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Vardenafil?
MediHelp rates the interaction as minor. Fostamatinib and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite R406 modestly inhibits CYP3A4 and can increase exposure to CYP3A4 substrates such as vardenafil. This may increase vasodilatory adverse effects.
How serious is the interaction between Fostamatinib and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed; monitor for hypotension, headache and flushing and reduce the vardenafil dose if these occur.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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