Drug interactions
Fostamatinib + Verapamil
Severity: Moderate
Fostamatinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein and can increase exposure to P-gp substrates such as verapamil. This may increase verapamil effects including hypotension, bradycardia and conduction delay.
What this interaction means in plain words
Fostamatinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Tamatinib inhibits intestinal and other P-glycoprotein efflux, increasing verapamil absorption and exposure.
What to do
Monitor blood pressure, heart rate and ECG when fostamatinib is started. Lower the verapamil dose if signs of excess effect occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Verapamil?
MediHelp rates the interaction as moderate. Fostamatinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein and can increase exposure to P-gp substrates such as verapamil. This may increase verapamil effects including hypotension, bradycardia and conduction delay.
How serious is the interaction between Fostamatinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when fostamatinib is started. Lower the verapamil dose if signs of excess effect occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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