Drug interactions
Fostemsavir + Hydroxychloroquine
Severity: Moderate
Fostemsavir and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval. Fostemsavir has been linked to QT prolongation at supratherapeutic exposures, so combining it with hydroxychloroquine may add to the risk of torsades de pointes, especially in patients with other risk factors.
What this interaction means in plain words
Fostemsavir and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic QTc prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG and monitor QTc during co-therapy, and correct potassium and magnesium abnormalities. Avoid adding other QT-prolonging drugs and reconsider the combination if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Fostemsavir and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval. Fostemsavir has been linked to QT prolongation at supratherapeutic exposures, so combining it with hydroxychloroquine may add to the risk of torsades de pointes, especially in patients with other risk factors.
How serious is the interaction between Fostemsavir and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during co-therapy, and correct potassium and magnesium abnormalities. Avoid adding other QT-prolonging drugs and reconsider the combination if QTc becomes markedly prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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