Drug interactions
Fostemsavir + Pravastatin
Severity: Moderate
Fostemsavir and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite may increase pravastatin exposure, raising the risk of myopathy.
What this interaction means in plain words
Fostemsavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Pravastatin belongs to Cardiovascular.
Why it happens
Temsavir inhibits OATP1B1/1B3, reducing hepatic uptake of pravastatin.
What to do
Use the lowest pravastatin dose needed and monitor for muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Pravastatin?
MediHelp rates the interaction as moderate. Fostemsavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir's active metabolite may increase pravastatin exposure, raising the risk of myopathy.
How serious is the interaction between Fostemsavir and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest pravastatin dose needed and monitor for muscle pain or weakness.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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