Drug interactions
Fostemsavir + Sevoflurane
Severity: Moderate
Fostemsavir and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and fostemsavir has been associated with QTc prolongation at supratherapeutic doses. At the recommended dose the added risk is probably small, but it may matter in patients with other risk factors for arrhythmia.
What this interaction means in plain words
Fostemsavir and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization (QT prolongation).
What to do
Obtain a baseline ECG and correct potassium and magnesium before anesthesia in patients with other QT risk factors. Monitor the ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fostemsavir and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sevoflurane
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Sevoflurane?
MediHelp rates the interaction as moderate. Fostemsavir and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and fostemsavir has been associated with QTc prolongation at supratherapeutic doses. At the recommended dose the added risk is probably small, but it may matter in patients with other risk factors for arrhythmia.
How serious is the interaction between Fostemsavir and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before anesthesia in patients with other QT risk factors. Monitor the ECG perioperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
