Drug interactions
Fostemsavir + Tiotropium-olodaterol
Severity: Moderate
Fostemsavir and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QT prolongation at supratherapeutic exposures, and beta2 agonists can add to arrhythmia risk through hypokalemia and tachycardia. At recommended doses the combined risk is modest but may matter in susceptible patients.
What this interaction means in plain words
Fostemsavir and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Potential additive QT prolongation, with beta2-agonist hypokalemia and sympathetic stimulation.
What to do
Obtain an ECG in patients with QT risk factors and keep potassium within normal range. Avoid exceeding recommended fostemsavir doses or adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Fostemsavir and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QT prolongation at supratherapeutic exposures, and beta2 agonists can add to arrhythmia risk through hypokalemia and tachycardia. At recommended doses the combined risk is modest but may matter in susceptible patients.
How serious is the interaction between Fostemsavir and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with QT risk factors and keep potassium within normal range. Avoid exceeding recommended fostemsavir doses or adding other QT-prolonging drugs.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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